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ZMapp - Information Sheet

                                                        

ZMapp TM is the result of a collaboration between Mapp Biopharmaceutical Inc. and LeafBio (San Diego, CA), Defyrus Inc. (Toronto, Canada), the U.S. government and the Public Health Agency of Canada (PHAC).

ZMapp TM is composed of three “humanized” monoclonal antibodies manufactured in plants, specifically Nicotiana.  It is an optimized cocktail combining the best components of MB-­‐003 (Mapp) and ZMAb (Defyrus/PHAC).

ZMapp TM was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans.  As such very little of the drug is currently available.  

Any decision to use an experimental drug in a patient would be a decision made by the treating physician under the regulatory guidelines of the FDA.

Mapp and its partners are cooperating with appropriate government agencies to increase production as quickly as possible.

CLICK HERE - ZMapp - Information Sheet (1 page .PDF file)

http://www.mappbio.com/

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Experimental Ebola Serum Grown in Tobacco Leaves

                                                     

webmd.com - by Brenda Goodman - reviewed by Michael W. Smith, MD

Aug. 4, 2014 -- ZMapp, the experimental treatment rushed to two Americans infected with Ebola in Africa, is grown in specially modified leaves of tobacco -- a plant better known for harming health than healing.

“We complied with a request from Emory University and Samaritan’s Purse to provide a very limited amount of ZMapp last week,” says David Howard, a spokesman for Reynolds American Services, the parent company of Kentucky BioProcessing. The small biopharma company in Owensboro, KY, has been contracted to grow the drug.

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9 Questions About this New Ebola Drug

      

cnn.com - by By Jacque Wilson and Danielle Dellorto - August 5, 2014

(CNN) -- Two American missionary workers infected with the deadly Ebola virus were given an experimental drug that seems to have saved their lives.

Dr. Kent Brantly was given the medication, ZMapp, shortly after telling his doctors he thought he would die, according to a source familiar with his case. Within an hour, doctors say his symptoms -- labored breathing and a widespread rash -- dramatically improved. Nancy Writebol, another missionary working with Samaritan's Purse, received two doses of the medication and has also shown significant improvement, sources say.

As there is no proven treatment and no vaccine for Ebola, this experimental drug is raising lots of questions.

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Ebola - Information, FAQs and Research

An expanding list of information resources on Ebola Virus Disease (EVD).  A link to additional information and a timeline of related events for this outbreak will be provided (in red - here), and at the bottom of this post . . .  . . .

Office of Inspector General - Lead Inspector General Joint Strategic Oversight Plan on U.S. Government Activities: International Ebola Response and Preparedness
http://westafrica.mphise.resiliencesystem.org/lead-inspector-general-joint-strategic-oversight-plan-us-government-activities-international-ebola

Global Communities ALERT Weekly Reports
http://resiliencesystem.org/global-communities-alert-weekly-reports

US - HHS - Ebola Outbreak 2014: Information Resources
http://sis.nlm.nih.gov/dimrc/ebola_2014.html

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Secret serum likely saved Ebola patients

Three top secret, experimental vials stored at subzero temperatures were flown into Liberia last week in a last-ditch effort to save two American missionary workers who had contracted Ebola, according to a source familiar with details of the treatment.

On July 22, Dr. Kent Brantly woke up feeling feverish. Fearing the worst, Brantly immediately isolated himself. Nancy Writebol's symptoms started three days later. A rapid field blood test confirmed the infection in both of them after they had become ill with fever, vomiting and diarrhea.

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Nigeria Confirms Doctor as 2nd Ebola Case

Nigerian authorities on Monday confirmed a second case of Ebola in Africa's most populous country, an alarming setback as officials across the region battle to stop the spread of a disease that has killed more than 700 people.

Also Monday, health authorities in Liberia ordered that all those who die from Ebola be cremated after communities opposed having the bodies buried nearby. Over the weekend, health authorities in the West African country encountered resistance while trying to bury 22 bodies in Johnsonville, outside the capital Monrovia. Military police helped restore order.

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2nd Ebola case confirmed in Nigeria

Nigerian authorities on Monday confirmed a second case of Ebola in Africa's most populous country. The emergence of a second case raises serious concerns about the infection control practices in Nigeria, and also raise the spectre that more cases could emerge. It can take up to 21 days after exposure to the virus for symptoms to appear.

Nigerian authorities said a total of 70 people are under surveillance and that they hoped to have eight people in quarantine by the end of Monday in an isolation ward in Lagos. The emergence there is particularly worrisome because Lagos is the largest city in Africa with some 21 million people.

Nigeria is the fourth country to report Ebola cases and at least 728 other people have died in Guinea, Sierra Leone and Liberia.

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Fièvre hémorragique ebola : l’hôpital de Labé initie une sensibilisation porte-à-porte.

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Suite à la propagation d'ebola, cette peste des temps modernes qui continue à gagner du terrain aussi bien en Guinée que dans la sous-région ouest-africaine, une nouvelle riposte se prépare de part et d’autre. Après la récente rencontre à Conakry des chefs d’État et de gouvernement des États membres de l’union du fleuve Mano, la direction générale de l’hôpital régionale de Labé n’a pas voulu être en reste.

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Woman dies after flying to Gatwick from Ebola hit Sierra Leone

 

A woman has died after landing at Gatwick airport on a flight from Sierra Leone, one of the countries at the centre of the deadly Ebola outbreak.

The 72-year-old was understood to have been “vomiting and sweating” before she collapsed and was taken by ambulance to hospital.

She had been travelling on a Gambia Bird flight with 128 passengers on board from Sierra Leone, which has declared a state of emergency after more than 200 people have died in the country from the disease.

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Living in the shadow of Ebola

 

As West African nations try to stop the deadly Ebola virus from spreading, people living in the affected countries are nervous. In Sierra Leone, communities are keeping a close eye on the exact locations where the disease has emerged.

The posters are crudely drawn and graphic. There's one pasted to the wall of the squat, concrete community centre in Kroo Bay, a slum in the centre of the capital Freetown, the kind of place where you can imagine disease spreading fast.

The houses are built of breeze block and have battered, rusting roofs. The spaces between them are piled with garbage, small children with no shoes tote yellow plastic jerry cans of water through the narrow lanes.

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