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Experimental Ebola drug shelved; study explores virus clearance

CENTER FOR INFECTIOUS DISEASE POLICY AND RESEARCH by Lisa Schnirring     July 20, 2015

Tekmira Pharmaceuticals  announced that it has suspended development of TKM-Ebola, a drug cocktail that showed disappointing human trial results in West Africa, as a convalescent plasma trial at a Doctors Without Borders (MSF) facility in Guinea proceeded with no ill effects in patients so far...

In suspending TKM-Ebola development, the company said that a joint reevaluation of its contract with the US Department of Defense is under way.

In another development, MSF said a convalescent serum trial at its facility in Nongo, Guinea, has enrolled 101 people over the last few months, with no ill effects reported so far, according to a Jul 17 update on the outbreak. Patients at the Nongo treatment unit have the option to receive plasma donated by Ebola survivors....

Meanwhile, detailed testing at a Swiss hospital on a 43-year-old doctor infected with Ebola in Sierra Leone found that viral decay occurred in two phases, once starting 72 hours after symptom onset before any antiviral interventions, with acceleration in viral load decay after ZMAb infusion and oral favipiravir treatments began..

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Ebola crisis update MSF

 

MSF                                                  July 17, 2015

Though Ebola has faded from the news headlines, the epidemic in West Africa continues to claim lives today. Around 30 people become infected each week in Sierra Leone and Guinea – a number that would be considered a major disaster under normal circumstances – and the outbreak has recently re-emerged in Liberia.

  • Liberia: After being declared Ebola-free on 9May, six (6) new cases have been confirmed since the re-emergence of the virus at the end of June.
  • Guinea: 13 confirmed cases in the country in the week to 12July in three main hotspots (Forecariah, Boké/Fria, Conakry)
  • Sierra Leone: 14 confirmed cases in the country in the week to 12July in three main hotspots (Freetown, Port Loko, Kambia).  

Read complete report:

http://www.msf.org/article/ebola-crisis-update-17-july-2015

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Guinea's president on global aid push: 'Ebola forced us to change completely'

After the international community pledged $3.4bn for West Africa, Alpha Condé is cautiously optimistic and taking stock of lessons learned

Guinean president Alpha Conde speaks to UN members during an International Ebola Recovery Conference on 10 July. Photograph: EDUARDO MUNOZ ALVAREZ/AFP/Getty Images

THE GUARDIAN by Raya Jababi                        June 11, 2015
NEW YORK--More than a year after the charity Médecins Sans Frontières sounded the alarm on the Ebolaepidemic that would claim more than 11,000 lives, the international community on Friday pledged $3.4bn to help affected West African countries recover.

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Video - The Story of Ebola

CLICK HERE - Global Health Media - The Story of Ebola - English

June 26, 2015

This animation—produced in collaboration with International Federation of Red Cross and Red Crescent Societies, UNICEF, and Yoni Goodman—brings to life key messages that help people see and understand how Ebola spreads and how to protect themselves and their communities.

CLICK HERE - About the film:

The story features a young girl whose grandfather dies from Ebola and puts the rest of her family at risk. The film makes visible the invisible Ebola germs to help people see and understand how Ebola spreads and how to protect themselves. Critical messages are woven through the story so that people better understand Ebola, see themselves within the context of an outbreak, and see how to act in ways that can keep themselves safe from the disease and protect their communities.

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WHO Ebola Situation Report - July 1, 2015 | UNMEER External Situation Report - June 29, 2015

                     

who.int - July 1, 2015                                                                         ebolaresponse.un.org - June 29, 2015

CLICK HERE - WHO Ebola Situation Report - July 1, 2015

CLICK HERE - UNMEER External Situation Report - June 29, 2015 - (2 page .PDF file)

CLICK HERE - WHO Ebola Situation Reports

CLICK HERE - UN Mission for Ebola Emergency Response (UNMEER) Situation Reports

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Finger-prick, blood test for Ebola takes just minutes

THE WASHINGTON POST by

Public health officials may soon be able to screen patients for Ebola at border crossings and hospitals with a finger-prick blood test that takes mere minutes.

The development of the rapid diagnostic test, reported in The Lancet Thursday, represents a significant victory for scientists around the world who have been experimenting over the past year with all manner of vaccines, treatments and other ways of eradicating the virus.

Developing a way of confirming Ebola in a patient has been one of the top priorities. In the early stages the symptoms -- chest pain, cough, nausea -- can look like many other illnesses, making it very difficult for doctors to triage -- to determine who should be quarantined and who to send home. It can often take days or longer for laboratory tests, the current standard, to return a positive or negative result.

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Neglected Tropical Diseases in the Ebola- Affected Countries of West Africa

PLOS   EDITORIAL by Peter J. Hotez, Sabin Vaccine Institute                          June 25, 2015
While global attention in West Africa is focused on the emergence of Ebola virus infection, new information from the published literature and World Health Organization databases reveals that many other neglected tropical diseases (NTDs) are far more widespread and also require urgent attention.
Well before Ebola virus infection emerged in West Africa at the end of 2013, the three
major affected countries--Guinea, Liberia, and Sierra Leone were already known to
be highly affected by NTDs....
Today, new information from the recent literature and the World Health Organization
(WHO) Preventive Chemotherapy and Transmission (PCT) Control databases reveals that
NTDs remain widespread in Guinea, Liberia, and Sierra Leone.  An estimated
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Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis

LANCET by Patrick G. T. Walker and others                               Volume 15, No. 7, p825–832, July 2015
The ongoing Ebola epidemic in parts of west Africa largely overwhelmed health-care systems in 2014, making adequate care for malaria impossible and threatening the gains in malaria control achieved over the past decade. We quantified this additional indirect burden of Ebola virus disease.

We estimated the number of cases and deaths from malaria in Guinea, Liberia, and Sierra Leone from Demographic and Health Surveys data for malaria prevalence and coverage of malaria interventions before the Ebola outbreak. We then removed the effect of treatment and hospital care to estimate additional cases and deaths from malaria caused by reduced health-care capacity and potential disruption of delivery of insecticide-treated bednets. We modelled the potential effect of emergency mass drug administration in affected areas on malaria cases and health-care demand....

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Vaccine trial won’t cause Ebola - WHO

GRAPHIC ONLINE by Rebecca Quisacde-Duho and Rhodaline Oppong                              June 20, 2015

Rebecca Quaicoe-Duho & Rhodaline Oppong
Rebecca Quaicoe-Duho & Rhodaline Oppong
Rebecca Quaicoe-Duho & Rhodaline Oppong
Rebecca Quaicoe-Duho & Rhodaline Oppong

The World Health Organisation (WHO) has assured Ghanaians that the proposed Ebola vaccine trial will not cause Ebola in the country.

WHO says it views the safety of people as paramount and would, therefore, not overlook any wrongdoing in the development of a vaccine.

 The WHO Country Representative, Dr Magda Robalo, gave the assurance at a public sensitisation forum in Accra last Thursday....

 Recently, following public agitations, the Minister of Health, Mr Alex Segbefia, called for more consultation on the proposed Ebola vaccine trial which was to be undertaken at Hohoe in the Volta Region.

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Ebola showed aid delivery desperately needs an overhaul

REUTERS  by Stella Dawson                                                          JUNE 18, 2015

WASHINGTON -- The Ebola epidemic exposed long-standing holes in aid delivery,  which desperately needs an overhaul before the next international emergency hits, aid experts said on Thursday.

Supplies for the Ebola zone in West Africa wait to be loaded at New York's John F. Kennedy International Airport September 20, 2014. REUTERS/Carlo Allegri

Many of the shortcomings seen during the Haiti earthquake of slow responses and uncoordinated relief efforts were repeated during the Ebola crisis that erupted in West Africa a year ago, they said.

With Sierra Leone and Guinea continuing to report cases of the deadly virus, the international community must act urgently, said Carolyn Reynolds, external relations manager at the World Bank.

"We need to think outside the box," she said at a panel on global health preparedness held on Capitol Hill.

Read complete story.
www.trust.org/item/20150618215202-ilvea/?source=fiOtherNews2

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