Liberia

Lab technician and Ebola survivor Sukato Mandzomba (front) worked with Peter Piot (back) in 1976 and again in 2016.  Heidi Larson

CLICK HERE - STUDY - Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection

sciencemag.org - by Jon Cohen - December 14, 2017

Forty years after the first documented Ebola outbreak, some of the survivors still have antibodies against the virus, a new study reveals. The find bolsters the widely held assumption that Ebola survivors remain immune to the virus for life. The work may also help guide development of new medicines and clarify the long-term health consequences of an Ebola infection.

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gnnliberia.com - by Cholo Brooks - April 25, 2017

Police in Sinoe County, southeastern Liberia, are investigation the mysterious death of nine persons after a repass of one late Edwin Dunbar, former Proprietor of One Family Entertainment Center who died few weeks ago in Greenville following a 2-night wake keeping.

According to our contact, those who died mysteriously include five females and four males, our contact said specimens from the nine deceased have been taken to Buchanan, Grand Bassa County for testing to establish the actual cause of death.

As a result of this terrible incident, officers of the Liberia National Police have been deployed in the streets of Greenville using mega phones and requesting those who ate the repass to report themselves.

Our contact said the strange and disturbing situation has created panic among citizens of the County, with others leaving for their towns and villages for fear of the unexpected.

County Health Officer John Logan when asked by our contact to speak on this prevailing situation, as to what is responsible for the mysterious deaths declined to comment on the issue.

Boston University scientists curbed the host response to Ebola infection by inhibiting TLR4 in macrophages. (CDC Global CC BY 2.0)

CLICK HERE - Virology - Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages

fiercebiotech.com - by Amirah Al Idrus - March 23, 2017

The Ebola virus causes a disease that is often fatal, in part by infecting white blood cells called macrophages and disrupting their immune response. Boston University scientists found that using drugs that block the protein TLR4 can suppress this response and potentially control infection.

Macrophages are responsible for detecting and destroying pathogens, but the Ebola virus activates them through the Toll-like receptor 4 (TLR4) pathway, causing an inappropriate immune response. The Ebola-infected macrophages end up producing excess cytokines and chemokines—proteins that promote inflammation and worsen the disease.

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CLICK HERE - PNAS - Spatial and temporal dynamics of superspreading events in the 2014–2015 West Africa Ebola epidemic

bbc.com - by James Gallagher - February 14, 2017

The majority of cases in the world's largest outbreak of Ebola were caused by a tiny handful of patients, research suggests.

The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61%) were caused by 3% of infected people.

The young and old were more likely to have been "super-spreaders".

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CLICK HERE - Disease “superspreaders” were driving cause of 2014 Ebola epidemic

CLICK HERE - Superspreaders Drove Ebola Epidemic, Study Finds